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Research Associate - 2 Year Term

Date Posted: 06/22/2021
Req ID:5506
Faculty/Division: Temerty Faculty of Medicine
Department: Department of Molecular Genetics
Campus: St. George (Downtown Toronto)

 

Description:

POSITION TITLE:     Research Associate Position – Limited Term (2 year)

DEPARTMENT:         Molecular Genetics, Faculty of Medicine

SUPERVISOR:         Dr. James Rini

 

OVERVIEW:


The Department of Molecular Genetics in the Faculty of Medicine, University of Toronto invites applications for the position of Research Associate (Limited Term) to participate in research focused on a structural and biochemical characterization of: i) viral glycoproteins and their interactions with host cell receptors and antibodies and ii) glycosyltransferases and their substrate interactions.

 

QUALIFICATIONS:


Candidates require a Ph.D. with research expertise in structural biology, biochemistry, and molecular biology.  At least 3-5 years of postdoctoral experience in protein crystallography and electron cryomicroscopy, as well as first-authored peer-reviewed publications using these techniques is required.  Expertise in mammalian glycoprotein characterization including glycan analysis, binding studies and enzyme kinetics analysis using spectroscopic and other biophysical approaches including biolayer interferometry, surface plasmon resonance-based techniques and mass spectrometry is also required. Experience in the expression, purification and characterization of viral glycoproteins, mammalian glycosyltransferases and antibodies is also necessary.  Candidates must have experience preparing manuscripts for submission to peer reviewed publications/journals and in presenting findings at meetings and conferences. Candidates must also have experience designing, planning, and executing experiments and research. Strong organizational, interpersonal and communication skills are required, and a proven ability to work positively with others in a collaborative laboratory environment is an asset.  

 

KEY DUTIES:

 

  • Designing, planning, and executing research projects. 
  • Determining structures using protein crystallography, negative stain electron microscopy and electron cryomicroscopy.
  • The generation, purification and characterization of viral glycoproteins, host cell receptors, glycosyltransferases and their substrates, and antibodies from tissue culture.  The relevant techniques include recombinant DNA methods, mammalian cell tissue culture, protein purification by FPLC, gel electrophoresis (SDS, 2D gels and Western), binding and kinetic studies using SPR and BLI and mass spectrometry.
  • Reading published papers relevant to the experiments being performed and adapting procedures accordingly.
  • Liaising with collaborators and assisting in the compilation, analysis, and reporting of research findings to researchers within and outside of the program.
  • Preparing manuscripts for submission to peer reviewed publications/journals.
  • Presenting findings at local, national, and international conferences.

 

Beyond these responsibilities, the individual may be expected to participate in the preparation of grant applications and in the supervision of technical support personnel and research trainees. At all times, the individual is expected to support the overall research and teaching missions of the lab. 

 

The University of Toronto is strongly committed to diversity within its community and especially welcomes applications from racialized persons / persons of colour, women, Indigenous / Aboriginal People of North America, persons with disabilities, LGBTQ persons, and others who may contribute to the further diversification of ideas. All qualified incumbents are encouraged to apply; however, Canadians and permanent residents will be given priority.

 

Closing Date: 12/31/2021,11:59PM ET
Employee Group: Research Associate 
Appointment Type: Grant - Term 
Schedule: Full-Time
Pay Scale Group & Hiring Zone: R01 -- Research Associates (Limited Term): $46,819 - $87,785
Job Category: Research Administration & Teaching

All qualified candidates are encouraged to apply; however, Canadians and permanent residents will be given priority.

Diversity Statement
The University of Toronto is strongly committed to diversity within its community and especially welcomes applications from racialized persons / persons of colour, women, Indigenous / Aboriginal People of North America, persons with disabilities, LGBTQ2S+ persons, and others who may contribute to the further diversification of ideas.

As part of your application, you will be asked to complete a brief Diversity Survey. This survey is voluntary. Any information directly related to you is confidential and cannot be accessed by search committees or human resources staff. Results will be aggregated for institutional planning purposes. For more information, please see http://uoft.me/UP.

Accessibility Statement
The University strives to be an equitable and inclusive community, and proactively seeks to increase diversity among its community members. Our values regarding equity and diversity are linked with our unwavering commitment to excellence in the pursuit of our academic mission.

The University is committed to the principles of the Accessibility for Ontarians with Disabilities Act (AODA). As such, we strive to make our recruitment, assessment and selection processes as accessible as possible and provide accommodations as required for applicants with disabilities.

If you require any accommodations at any point during the application and hiring process, please contact uoft.careers@utoronto.ca.
All qualified candidates are encouraged to apply; however, Canadians and permanent residents will be given priority.


Job Segment: Biochemistry, Genetics, Research Associate, Laboratory, Science, Research